瘦素与高分子量脂联素的比值与男性的颈动脉内膜中层厚度独立相关，但与女性无关。
Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women.
机构信息
Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
出版信息
Biomarkers. 2010 Jun;15(4):340-4. doi: 10.3109/13547501003735532.
BACKGROUND
The leptin:adiponectin ratio (L:A ratio) is an independent predictor of carotid intima-media thickness (CIMT).
OBJECTIVE
To evaluate whether the leptin:high-molecular-weight adiponectin ratio (L:HA ratio) is associated with CIMT in the general population.
METHODS
We investigated the relationship between the L:HA ratio and CIMT in 233 Japanese study participants (106 men and 127 women).
RESULTS
After adjustment for confounding factors, CIMT was significantly correlated with the log L:HA ratio (beta = 0.11, p = 0.014) in men, whereas no correlation was observed in women (beta = 0.01, p = 0.50).
CONCLUSION
The L:HA ratio is closely correlated with CIMT in men, but not in women.
背景
瘦素：高分子量脂联素比值（L:A 比值）是颈动脉内膜中层厚度（CIMT）的独立预测因子。
目的
评估瘦素：高分子量脂联素比值（L:HA 比值）与普通人群 CIMT 的关系。
方法
我们调查了 233 名日本研究参与者（106 名男性和 127 名女性）中 L:HA 比值与 CIMT 之间的关系。
结果
在调整混杂因素后，男性的 CIMT 与 log L:HA 比值呈显著相关（β=0.11，p=0.014），而女性则无相关性（β=0.01，p=0.50）。
结论
L:HA 比值与男性的 CIMT 密切相关，但与女性无关。
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