Department of Internal Medicine, Division of Geriatric Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Am J Hypertens. 2010 May;23(5):501-7. doi: 10.1038/ajh.2010.8. Epub 2010 Feb 11.
Adiposity is associated with arterial stiffness, and both adiposity and arterial stiffness independently predict morbidity and mortality. Because adipocytes account for most adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness.
This is a cross-sectional analysis of data from the Baltimore Longitudinal Study of Aging (BLSA). Adiposity was measured as kilograms of abdominal adipose tissue using dual-energy X-ray absorptiometry (DXA). Arterial stiffness was assessed as carotid-femoral pulse wave velocity (PWV). Leptin, adiponectin, and resistin were assayed in fasting serum samples. The influence of adipokines on the relationship between adiposity and arterial stiffness by adipokines was examined using standard mediation pathway analysis.
Among 749 participants ages 26-96 years (mean age 67, 52% men, 27% black), abdominal adiposity was positively associated with PWV (relative ratio (RR) = 1.04, P = 0.02), after adjusting for potential confounders but was attenuated and no longer significant after adjusting for leptin (RR = 0.99, P = 0.77). The relationship between adiposity and PWV was not substantially influenced by adiponectin (RR = 1.03, P = 0.06) or resistin (RR = 1.05, P = 0.010). Leptin (RR = 1.02, P < 0.001), resistin (RR = 0.92, P < 0.0001), and adiponectin (RR = 0.97, P = 0.004), but not abdominal adiposity (RR = 1.00, P = 0.94), retained significant associations with PWV when adjusting for each other and confounders.
Our findings are consistent with the hypothesis that leptin explains, in part, the observed relationship between abdominal adiposity and arterial stiffness. Adiponectin, leptin, and resistin are independent correlates of PWV.
肥胖与动脉僵硬有关，肥胖和动脉僵硬均可独立预测发病率和死亡率。由于脂肪细胞产生大部分脂肪因子，因此本研究的目的是检查脂肪因子（如瘦素、脂联素和抵抗素）对腹部肥胖与动脉僵硬之间关系的影响。
这是对巴尔的摩纵向老龄化研究（BLSA）数据的横断面分析。使用双能 X 射线吸收法（DXA）测量腹部脂肪组织的肥胖程度。动脉僵硬作为颈股脉搏波速度（PWV）进行评估。在空腹血清样本中测定瘦素、脂联素和抵抗素。使用标准中介途径分析检查脂肪因子对脂肪因子与动脉僵硬之间关系的影响。
在 749 名年龄在 26-96 岁（平均年龄 67 岁，52%为男性，27%为黑人）的参与者中，腹部肥胖与 PWV 呈正相关（相对比（RR）=1.04，P=0.02），在调整了潜在混杂因素后，但在调整瘦素后减弱且不再显著（RR=0.99，P=0.77）。脂联素（RR=1.03，P=0.06）或抵抗素（RR=1.05，P=0.010）对肥胖与 PWV 之间的关系没有显著影响。瘦素（RR=1.02，P<0.001）、抵抗素（RR=0.92，P<0.0001）和脂联素（RR=0.97，P=0.004），而不是腹部肥胖（RR=1.00，P=0.94），在调整彼此和混杂因素后，与 PWV 仍保持显著相关性。
我们的发现与假设一致，即瘦素部分解释了观察到的腹部肥胖与动脉僵硬之间的关系。脂联素、瘦素和抵抗素是 PWV 的独立相关因素。
