Gembitskiĭ E V, Begunov A V
Klin Med (Mosk). 1991 Dec;69(12):59-63.
Cardiac pains related to estrogen therapy for prostatic cancer (PC) emerged in 53% of treated patients with ischemic heart disease (IHD). The pain complaints were associated with impairment of coronary circulation in 48% of cases. This clinical condition is attributed to elevated STH levels and a trend to hypercorticism. In hypertensive PC patients estrogens provoked more frequent and severe headaches which occurred at initial stages of the treatment in 23% and after 1-year administration of hormones in 44% of patients. Hypertensive reactions may be caused by aldosterone and prolactin hyperproduction. Observation of the therapist and endocrinologist can help to prevent complications in IHD patients with PC.
接受前列腺癌（PC）雌激素治疗的患者中，53%出现了与治疗相关的心脏疼痛，这些患者患有缺血性心脏病（IHD）。48%的病例中，疼痛主诉与冠状动脉循环受损有关。这种临床状况归因于生长激素（STH）水平升高和皮质醇增多症倾向。在高血压PC患者中，雌激素引发更频繁、更严重的头痛，23%的患者在治疗初期出现头痛，44%的患者在激素治疗1年后出现头痛。高血压反应可能由醛固酮和催乳素分泌过多引起。治疗师和内分泌学家的观察有助于预防PC合并IHD患者的并发症。
