Tunca Ayşe, Ardiçoğlu Yasemin, Kargili Ayşe, Adam Bahattin
Department of Neurology, Private Zafer Hospital, Ankara, Turkey.
Helicobacter. 2007 Feb;12(1):59-62. doi: 10.1111/j.1523-5378.2007.00470.x.
The aim of this study was to ascertain whether oxidative stress is a causative factor of migraine attacks for Helicobacter pylori-infected migraineurs.
A total of 35 consecutive migraine patients without aura who came to gastroenterology polyclinic with various complaints and diagnosed H. pylori infection were included in the study group and compared with a group of 29 patients (control group) without migraine and H. infection. H. pylori infection was diagnosed by histopathological biopsies, which were taken by endoscopy (Olympus-GIFXQ240 endoscope). Both the diagnosis and the classification of migraine were made according to the International Headache Society criteria. Blood samples for nitric oxide were taken from patients with migraine during headache-free period as well as the control group. The interaction of nitric oxide was measured by the determination of both nitrite and nitrate concentrations in the sample.
The study group included 31 women and 4 men (mean age 49 +/- 8 years) and the control group included 25 women and 4 men (mean age 52.6 +/- 11 years). The mean frequency of migraine attacks was 2.94 +/- 1.58 days/month and the mean duration of attacks was 21.2 +/- 3 hours. It was found that the study group has lower nitrate levels than the control group.
Our results do not support the role of oxidative stress in patients suffering from H. pylori infection and migraine.
本研究旨在确定氧化应激是否是幽门螺杆菌感染的偏头痛患者偏头痛发作的致病因素。
连续纳入35例因各种不适前来胃肠病多科门诊就诊且诊断为幽门螺杆菌感染的无先兆偏头痛患者作为研究组，并与29例无偏头痛且无幽门螺杆菌感染的患者（对照组）进行比较。幽门螺杆菌感染通过内镜检查（奥林巴斯GIFXQ240型内镜）获取组织病理学活检样本进行诊断。偏头痛的诊断和分类均依据国际头痛协会标准。在无头痛期采集偏头痛患者以及对照组患者的血液样本检测一氧化氮。通过测定样本中亚硝酸盐和硝酸盐浓度来测量一氧化氮的相互作用。
研究组包括31名女性和4名男性（平均年龄49±8岁），对照组包括25名女性和4名男性（平均年龄52.6±11岁）。偏头痛发作的平均频率为2.94±1.58天/月，发作的平均持续时间为21.2±3小时。发现研究组的硝酸盐水平低于对照组。
我们的结果不支持氧化应激在幽门螺杆菌感染和偏头痛患者中的作用。
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