Limmer J, Seifried E, Ellbrück D, Schwarz A
Allgemeinchirurgie, Universität Ulm.
Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir. 1990:1185-7.
In an open, randomized, controlled and prospective study we compared the efficacy of LMWH with unfractionated heparin (UFH) and the effects of both heparin preparations on haemostatic and fibrinolytic parameters. We also stratified subgroups which received HES intra- and postoperatively. The study groups were well matched with regard to baseline characteristics. With LMWH 4 patients (4.1%) displayed a positive fibrinogen uptake test (1 patient with HES). With UFH 5 patients (5%) demonstrated a positive uptake (3 patients with HES). Antifactor Xa levels were significant higher in the LMWH groups; all other fibrinolytic and haemostatic factors, bleeding and local wound complications did not differ. These data suggest that LMWH in equally effective and safe as UFH in general surgery. HES may have and additive effect.
在一项开放性、随机、对照的前瞻性研究中，我们比较了低分子肝素（LMWH）与普通肝素（UFH）的疗效，以及这两种肝素制剂对止血和纤溶参数的影响。我们还对术中及术后接受羟乙基淀粉（HES）的亚组进行了分层。研究组在基线特征方面匹配良好。使用LMWH的4例患者（4.1%）纤维蛋白原摄取试验呈阳性（1例使用HES的患者）。使用UFH的5例患者（5%）摄取试验呈阳性（3例使用HES的患者）。LMWH组的抗Xa因子水平显著更高；所有其他纤溶和止血因子、出血及局部伤口并发症并无差异。这些数据表明，在普通外科手术中，LMWH与UFH同样有效且安全。HES可能具有相加作用。
