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[人腺病毒2型六邻体的N端肽:其化学合成及抗原特性]

[The N-terminal peptide of the hexon of human adenovirus type 2: its chemical synthesis and antigenic properties].

作者信息

Tarasishin L A

出版信息

Mikrobiol Zh (1978). 1991 Sep-Oct;53(5):53-8.

PMID:1724282
Abstract

Peptides corresponding to the N-terminal section of protein of a hexone of the 2nd type human adenovirus have been synthesized. Being conjugated with a carrier of BSA they induced formation of antibodies which reacted both with peptides and with viral proteins. Sera to native proteins were also bound to synthetic peptides. Immunogenicity strengthening in peptides conjugated with synthetic polyelectrolytes is shown. The N-terminal section of hexon is supposed to participate in formation of an antigenic determinant possessing group specificity.

摘要

已合成了与第二种人类腺病毒六邻体蛋白N端部分相对应的肽段。将其与牛血清白蛋白载体偶联后,可诱导产生既能与肽段反应又能与病毒蛋白反应的抗体。针对天然蛋白的血清也能与合成肽段结合。结果表明,与合成聚电解质偶联的肽段免疫原性增强。推测六邻体的N端部分参与具有组特异性的抗原决定簇的形成。

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