Pathak Pankaj, Prasad Gaddamanugu L, Meziani Mohammed J, Joudeh Attalla A, Sun Ya-Ping
Department of Chemistry and Laboratory for Emerging Materials and Technology, Hunter Hall, Clemson University, Clemson, SC 29634, USA.
Langmuir. 2007 Feb 27;23(5):2674-9. doi: 10.1021/la062739d. Epub 2007 Jan 23.
The rapid expansion of a supercritical solution into a liquid solvent (RESOLV) technique with benign supercritical carbon dioxide was applied to obtain aqueous suspended nanoparticles of the highly potent anticancer drug paclitaxel. The paclitaxel nanoparticles were protected from agglomeration by using a known nontoxic stabilization agent. The aqueous suspended paclitaxel nanoparticles of different average particle sizes were evaluated in vitro against human breast cancer cells. The results suggest that the nanosized paclitaxel particles are effective, with an antineoplastic activity comparable to that of the commercial paclitaxel formulation. The technique should be generally applicable to the processing of nanoparticles from other important drugs with aqueous solubility problems.
采用超临界溶液快速膨胀进入液态溶剂（RESOLV）技术，以良性超临界二氧化碳制备了高效抗癌药物紫杉醇的水悬浮纳米颗粒。通过使用一种已知的无毒稳定剂防止紫杉醇纳米颗粒团聚。对不同平均粒径的水悬浮紫杉醇纳米颗粒进行了体外抗人乳腺癌细胞评估。结果表明，纳米级紫杉醇颗粒具有有效性，其抗肿瘤活性与市售紫杉醇制剂相当。该技术通常应适用于处理其他存在水溶性问题的重要药物的纳米颗粒。
