儿童化疗相关的指甲变化。
Nail changes associated with chemotherapy in children.
作者信息
Chen W, Yu Y-S, Liu Y-H, Sheen J-M, Hsiao C-C
机构信息
Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung Medical Centre, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
出版信息
J Eur Acad Dermatol Venereol. 2007 Feb;21(2):186-90. doi: 10.1111/j.1468-3083.2006.01887.x.
BACKGROUND
Large series of chemotherapy-induced nail changes in children have rarely been reported in the literature.
OBJECTIVE
To study the pattern and onset of nail changes in cancer children receiving various chemotherapy regimens.
METHODS
A cross-sectional study was performed on 30 paediatric patients (aged 1-17, mean 8.3 years), including 11 with acute lymphoblastic leukaemia, five with acute myeloid leukaemia, and others.
RESULTS
Nail changes developed in 10 children during chemotherapy, five of whom had Muehrcke's lines, three Beau's lines, one Mees' lines and another had trachyonychia. There appeared to be no correlation between the pattern of nail alteration and the underlying cancer types or stages, or the regimens of chemotherapy.
CONCLUSION
One third of the children with cancers developed nail changes associated with chemotherapy. Among them, Muehrcke's lines were the most common manifestation, which were unrelated to hypoalbuminaemia in our series.
背景
文献中很少有关于儿童化疗引起指甲改变的大量系列报道。
目的
研究接受各种化疗方案的癌症儿童指甲改变的模式和发病情况。
方法
对30例儿科患者（年龄1 - 17岁，平均8.3岁）进行横断面研究，其中包括11例急性淋巴细胞白血病患者、5例急性髓细胞白血病患者及其他患者。
结果
10名儿童在化疗期间出现指甲改变，其中5例有穆勒克线，3例有博氏线，1例有米氏线，另1例有糙皮病样指甲。指甲改变的模式与潜在的癌症类型、分期或化疗方案之间似乎没有相关性。
结论
三分之一的癌症儿童出现了与化疗相关的指甲改变。其中，穆勒克线是最常见的表现，在我们的系列研究中与低白蛋白血症无关。
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