Pickering Chris, Moreira Tiago, Liljequist Sture
Department of Clinical Neuroscience, Division of Drug Dependence Research, Karolinska Institutet, Stockholm, Sweden.
Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):109-14. doi: 10.1111/j.1742-7843.2006.00002.x.
In a previous report, we found that a 5-min. delay in alcohol access increases ethanol intake in rats trained to self-administer 5% ethanol. To assess the effects of this delay on the motivation to self-administer ethanol, Wistar rats were trained on a progressive ratio schedule of reinforcement and presented with the 5-min. delay. There was no change in break point (6 presses/delivery), active (125 presses/30 min.) or inactive (10 presses/30 min.) lever presses after the 5-min. delay compared to baseline. However, response cessation occurred 10 min. earlier in this delay session compared to baseline indicating that consumption was accelerated by delayed access to alcohol.
在之前的一份报告中，我们发现，对于训练有素的能自行摄入5%乙醇的大鼠，给予5分钟的酒精获取延迟会增加乙醇摄入量。为了评估这种延迟对自行摄入乙醇动机的影响，将Wistar大鼠训练至采用渐进比率强化程序，并给予5分钟的延迟。与基线相比，5分钟延迟后，断点（每给药一次按压6次）、主动（30分钟内按压125次）或被动（30分钟内按压10次）杠杆按压次数均无变化。然而，与基线相比，在该延迟实验中反应停止提前了10分钟，这表明延迟获取酒精会加速酒精消耗。
