Tsibul'kin A P, Arleevskaia M I, Shcherbatenko L A
Lab Delo. 1991(8):57-9.
Heparin elevates the level of NBT-positive monocytes in donors and patients with osteoarthrosis deformans and rheumatoid arthritis. Patient's rheumatoid arthritis cells were found the most sensitive to heparin. Excessive heparin-dependent activity of monocytes in this case reflects the activity of the rheumatoid process, the NBT test with heparin being more sensitive in the diagnosis of disease activity than measurement of red cell sedimentation rate or of blood C-reactive protein, gamma- and alpha 2-globulin levels.
肝素可提高骨关节炎畸形患者及类风湿性关节炎患者和供体中NBT阳性单核细胞的水平。发现类风湿性关节炎患者的细胞对肝素最为敏感。在这种情况下，单核细胞过度的肝素依赖性活性反映了类风湿过程的活性，与测量红细胞沉降率、血液C反应蛋白、γ和α2球蛋白水平相比，肝素NBT试验在诊断疾病活动方面更为敏感。
