Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Genetics. 1983 Jul;104(3):485-95. doi: 10.1093/genetics/104.3.485.
Methods are proposed for estimating the parameters in the frequency spectrum derived from the model of Langley, Brookfield and Kaplan for the evolution of a transposable element in a finite Mendelian population. Statistical properties of these estimates are studied, and the results are supported with simulation data. The effects on the estimates caused by possible insensitivities of the experimental technique are also discussed. To illustrate the proposed methodology, the data of Montgomery and Langley are analyzed.
提出了一种估计 Langley、Brookfield 和 Kaplan 模型中可移动元素在有限孟德尔群体中演化的频谱参数的方法。研究了这些估计的统计性质,并通过模拟数据支持了结果。还讨论了实验技术可能的不敏感性对估计的影响。为了说明所提出的方法,分析了蒙哥马利和兰利的数据。