Center for Demographic and Population Genetics, University of Texas at Houston, Houston, Texas 77025.
Genetics. 1983 Jul;104(3):531-48. doi: 10.1093/genetics/104.3.531.
A new procedure is proposed for estimating the effective population size, given that information is available on changes in frequencies of the alleles at one or more independently segregating loci and the population is observed at two or more separate times. Approximate expressions are obtained for the variances of the new statistic, as well as others, also based on allele frequency changes, that have been discussed in the literature. This analysis indicates that the new statistic will generally have a smaller variance than the others. Estimates of effective population sizes and of the standard errors of the estimates are computed for data on two fly populations that have been discussed in earlier papers. In both cases, there is evidence that the effective population size is very much smaller than the minimum census size of the population.
提出了一种新的方法来估计有效种群大小，前提是可以获得一个或多个独立分离基因座上等位基因频率变化的信息，并且可以在两个或更多不同时间观察到该种群。得到了新统计量以及其他基于等位基因频率变化的统计量的方差的近似表达式，这些统计量在文献中也有所讨论。分析表明，新统计量通常具有比其他统计量更小的方差。对之前文献中讨论过的两个蝇种群的数据进行了有效种群大小及其估计标准误差的计算。在这两种情况下，都有证据表明有效种群大小远小于种群的最小普查规模。
