Mozes S, Kuchár S, Michalov M, Nováková V
Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Czechoslovakia.
Physiol Behav. 1991 Dec;50(6):1133-6. doi: 10.1016/0031-9384(91)90573-7.
The nutritional status in the early postnatal period may significantly influence the development and functional activity of food intake regulating mechanisms. Therefore we investigated the weight gains and total RNA content of the ventromedial (VMH) and lateral (LHA) hypothalamic cells of rat pups in normal litters (8 pups/nest) and in reduced litters (2 pups/nest) reared permanently (from birth to weaning) or temporarily (from 1st to 5th day) in reduced nests. A significant decrease of weight gains was found in pups reared in reduced litters during the first 5 days which resulted in significant differences of body weight between the pups from normal and reduced litters on 5th day of life. On the 15th and 30th days, there were no significant differences in body weight between these animals, but the RNA content in VMH cells of pups reared in reduced litters was significantly increased on the 15th and 30th days. The RNA content in the LHA cells was unchanged. The results show that reducing a rat litter to 2 pups caused short-term undernutrition leading to permanent changes of the RNA content in the VMH neurons. The possible consequences of the permanently changed RNA content of this hypothalamic structure are discussed.
出生后早期的营养状况可能会显著影响食物摄入调节机制的发育和功能活动。因此，我们研究了正常窝仔（每窝8只幼崽）和减少窝仔（每窝2只幼崽）中大鼠幼崽腹内侧（VMH）和外侧下丘脑（LHA）细胞的体重增加和总RNA含量，这些幼崽在减少的窝中永久性（从出生到断奶）或临时性（从第1天到第5天）饲养。发现在减少窝仔中饲养的幼崽在头5天体重增加显著下降，这导致在出生后第5天正常窝和减少窝的幼崽之间体重有显著差异。在第15天和第30天，这些动物之间的体重没有显著差异，但在减少窝仔中饲养的幼崽的VMH细胞中的RNA含量在第15天和第30天显著增加。LHA细胞中的RNA含量没有变化。结果表明，将一窝大鼠幼崽减少到2只导致短期营养不良，从而导致VMH神经元中RNA含量的永久性变化。本文讨论了这种下丘脑结构中RNA含量永久性改变的可能后果。
