Zhang W M, Kuchár S, Mozes S
Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovakia.
Brain Res Bull. 1994;35(4):383-5. doi: 10.1016/0361-9230(94)90118-x.
The RNA content of the ventromedial hypothalamus (VMH), the lateral hypothalamic area (LHA), and the cortical neurons of male and female rats, neonatally treated with monosodium glutamate (MSG), were investigated. MSG (2 g/kg b.wt.) was injected subcutaneously to male and female rat pups daily for 5 days after birth. At 12 weeks of age a significant decrease of RNA content in the VMH cells and significantly increased body fat in neonatally MSG-treated animals were found. Correlation of these data showed a significant negative correlation between the body fat content and the RNA content in VMH neurons. The results a) confirm a closed relationship between the body fat content and the functional activity of VMH, b) indicate that obesity of neonatally MSG-treated animals should be due to decreased functional activity of the VMH cells.
研究了新生期经谷氨酸钠（MSG）处理的雄性和雌性大鼠腹内侧下丘脑（VMH）、外侧下丘脑区（LHA）及皮层神经元的RNA含量。在出生后5天，每天给雄性和雌性幼鼠皮下注射MSG（2 g/kg体重）。在12周龄时，发现新生期经MSG处理的动物VMH细胞中的RNA含量显著降低，且体脂显著增加。这些数据的相关性表明，体脂含量与VMH神经元中的RNA含量之间存在显著负相关。结果：a）证实了体脂含量与VMH功能活性之间存在密切关系；b）表明新生期经MSG处理的动物肥胖应归因于VMH细胞功能活性降低。
