Piven' N N, Smirnova V I, Kapliev V I, Podzolkova G G, Khrapova N P
Zh Mikrobiol Epidemiol Immunobiol. 1991 Oct(10):8-12.
As established with the use of electron-immunochemical techniques, glycoprotein antigen 6 is the outer membrane component of P. pseudomallei cell wall, while glycoprotein antigen 8 is localized on the cell surface as a capsule-like formation. Antigen 6 plays no perceptible role in the realization of the pathogenic properties of the infective agent, but serves as a reliable sign in the differentiation of P. pseudomallei strains into serovars. Subcultures, defective in the synthesis of antigen 8, have sharply reduced virulence for laboratory animals. As revealed in this study, the pathogenetic action of antigen 8 is linked with its pronounced antiphagocytic function. Thus, antigen 8 is considered to be one of the key pathogenicity factors of P. pseudomallei.
通过电子免疫化学技术确定，糖蛋白抗原6是类鼻疽杆菌细胞壁的外膜成分，而糖蛋白抗原8以胶囊样结构定位于细胞表面。抗原6在病原体致病特性的实现中没有明显作用，但作为将类鼻疽杆菌菌株分化为血清型的可靠标志。抗原8合成有缺陷的传代培养物对实验动物的毒力大幅降低。如本研究所示，抗原8的致病作用与其明显的抗吞噬功能有关。因此，抗原8被认为是类鼻疽杆菌的关键致病因素之一。
