利用单克隆抗体对近期甲型H1N1流感病毒进行抗原分析。
Antigenic analysis of recent H1N1 influenza viruses with monoclonal antibodies.
作者信息
Yamada A, Cao M S, Imanishi J, Oyama S, Abe A, Katagiri S
机构信息
Department of Microbiology, Kyoto Prefectural University of Medicine, Japan.
出版信息
Acta Virol. 1991 Aug;35(4):343-9.
Antigenic analysis of recently isolated H1 influenza viruses was performed using haemagglutination inhibition (HI) assay with monoclonal antibodies to the haemagglutinin (HA) subunit. Tests using monoclonal antibodies against the HA of the A/England/333/80 (H1N1) and A/Yamagata/120/86 (H1N1) viruses revealed that the major antigenic drift occurred in 1985 or 1986 and A/Dunedin/6/83-like virus became a major strain after 1986.
使用针对血凝素（HA）亚基的单克隆抗体，通过血凝抑制（HI）试验对最近分离的H1流感病毒进行了抗原分析。使用针对A/英格兰/333/80（H1N1）和A/山形/120/86（H1N1）病毒HA的单克隆抗体进行的测试表明，主要抗原漂移发生在1985年或1986年，1986年后A/达尼丁/6/83样病毒成为主要毒株。
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