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多基因在随机环境下的行为。二、加性模型中的连锁不平衡。

Multilocus Behavior in Random Environments. II. Linkage Disequilibrium in an Additive Model.

机构信息

Department of Biology, G7, University of Pennsylvania, Philadelphia, Pennsylvania, 19174.

出版信息

Genetics. 1977 Nov;87(3):569-79. doi: 10.1093/genetics/87.3.569.

DOI:10.1093/genetics/87.3.569
PMID:17248779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213762/
Abstract

The effect of a stochastic environment on an additive, two-locus model of a diploid population is examined. The appropriate diffusion equation is derived and its asymptotic properties are approximated by an Orstein-Uhlenbeck process. The first and second order moments of this approximating process are given. The mean linkage disequilibrium will be nonzero if the alleles at the different loci are correlated. The sign of the mean disequilibrium is determined by the sign of the correlation.

摘要

考察了随机环境对二倍体群体的加性双位点模型的影响。推导出了相应的扩散方程，并通过 Orstein-Uhlenbeck 过程对其渐近性质进行了近似。给出了该近似过程的一阶和二阶矩。如果不同位点的等位基因相关，则连锁不平衡的均值将不为零。平均不平衡的符号由相关的符号决定。

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本文引用的文献

1
Linkage disequilibrium in subdivided populations.细分群体中的连锁不平衡。
Genetics. 1973 Sep;75(1):213-9. doi: 10.1093/genetics/75.1.213.
2
Population genetics of marine pelecypods. 3. Epistasis between functionally related isoenzymes of Mytilus edulis.海洋双壳贝类的群体遗传学。3. 紫贻贝功能相关同工酶之间的上位性。
Genetics. 1973 Mar;73(3):487-96. doi: 10.1093/genetics/73.3.487.
3
Uncorrelated genetic drift of gene frequencies and linkage disequilibrium in some models of linked overdominant polymorphisms.
Genet Res. 1974 Dec;24(3):281-94. doi: 10.1017/s0016672300015287.
4
Multilocus behavior in random environments. I. Random Levene models.随机环境中的多位点行为。I. 随机莱文模型。
Genetics. 1976 Jan;82(1):123-37. doi: 10.1093/genetics/82.1.123.
5
Gene flow and selection in a two-locus system.双基因座系统中的基因流动与选择
Genetics. 1975 Dec;81(4):787-802. doi: 10.1093/genetics/81.4.787.
6
Subdivided populations: a review of the one- and two-locus deterministic theory.
Theor Popul Biol. 1975 Feb;7(1):13-38. doi: 10.1016/0040-5809(75)90003-9.