随机交配群体中多位点近亲繁殖系数的预测及其与连锁不平衡的关系。
Prediction of multi-locus inbreeding coefficients and relation to linkage disequilibrium in random mating populations.
作者信息
Hill William G, Weir Bruce S
机构信息
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK.
出版信息
Theor Popul Biol. 2007 Sep;72(2):179-85. doi: 10.1016/j.tpb.2006.05.006. Epub 2007 May 16.
Abstract
An algorithm to predict the level of identity by descent simultaneously at multiple loci is presented, which can in principle be extended to any number of loci. The model assumes a random mating population, with random association of haplotypes. The relationship is shown between coefficients of multi-locus identity or non-identity by descent and moments of multi-locus linkage disequilibrium. Thus, these moments can be computed from the multilocus identity or, using algorithms derived previously to predict the disequilibria moments, vice-versa. The results can be applied to predict multi-locus identity in, for example, gene mapping.
摘要
本文提出了一种在多个基因座上同时预测同源性水平的算法，原则上该算法可扩展到任意数量的基因座。该模型假设群体随机交配，单倍型随机关联。文中展示了多位点同源或非同源系数与多位点连锁不平衡矩之间的关系。因此，这些矩可以从多位点同源性计算得出，或者使用先前推导的算法来预测不平衡矩，反之亦然。研究结果可应用于例如基因定位中多位点同源性的预测。
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