四分子数据连锁与干扰的最大似然估计。
Maximum likelihood estimation of linkage and interference from tetrad data.
机构信息
Department of Genetics, University of California, Davis, California 95616.
出版信息
Genetics. 1979 May;92(1):231-45. doi: 10.1093/genetics/92.1.231.
Abstract
Maximum likelihood equations have been derived for estimation of map distance and interference from two-point and ranked tetrad data. The estimators have been applied to data from Saccharomyces cerevisiae and Schizosaccharomyces pombe. S. cerevisiae consistently shows quite strong interference over the mapped genome. In striking contrast, S. pombe consistently shows much weaker interference and many crosses exhibit negative interference. In neither species was there a conspicuous tendency for intervals spanning a centromere to show less interference than those that did not. Since the amount of recombination per microgram of DNA in the two species is similar, the difference in interference characteristics seems to be a reflection of some fundamental difference in the recombination process of the two species.
摘要
已推导出两点和分级四分子数据估计图谱距离和干涉的最大似然方程。这些估计值已应用于来自酿酒酵母和裂殖酵母的数据。酿酒酵母在整个映射基因组上始终表现出相当强的干涉。相比之下，裂殖酵母的干涉明显较弱，许多杂交显示负干涉。在这两个物种中，跨越着丝粒的间隔并不比不跨越着丝粒的间隔表现出明显较少的干涉。由于这两个物种中每微克 DNA 的重组量相似，干扰特征的差异似乎反映了这两个物种的重组过程中的一些根本差异。
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