King J S, Mortimer R K
Graduate Group in Biophysics, University of California, Berkeley 94720.
Genetics. 1991 Oct;129(2):597-602. doi: 10.1093/genetics/129.2.597.
In determining genetic map distances it is necessary to infer crossover frequencies from the ratios of recombinant and parental progeny. To do this accurately, in intervals where multiple crossovers may occur, a mathematical model of chiasma interference must be assumed when mapping in organisms displaying such interference. In Saccharomyces cerevisiae the model most frequently used is that of R.W. Barratt. An alternative to this model is presented. This new model is implemented using a microcomputer and standard numerical methods. It is demonstrated to fit ranked tetrad data from Saccharomyces more closely than the Barratt model and thus generates more accurate estimates of map distances when used with two-point data. A computer program implementing the model has been developed for use in calculating map distances from tetrad data in Saccharomyces.
在确定遗传图谱距离时，有必要从重组子代和亲本子代的比例中推断交换频率。为了准确做到这一点，在可能发生多次交换的区间内，当在表现出这种干扰的生物体中进行图谱绘制时，必须假定一个交叉干扰的数学模型。在酿酒酵母中，最常用的模型是R.W.巴拉特模型。本文提出了该模型的一种替代方案。这个新模型是使用微型计算机和标准数值方法实现的。结果表明，与巴拉特模型相比，它能更紧密地拟合酿酒酵母的排序四分体数据，因此在与两点数据一起使用时，能产生更准确的图谱距离估计值。已经开发了一个实现该模型的计算机程序，用于根据酿酒酵母的四分体数据计算图谱距离。
