Honkanen R, Ertama L, Linnoila M, Alha A, Lukkari I, Karlsson M, Kiviluoto O, Puro M
Br Med J. 1980 Nov 15;281(6251):1309-12. doi: 10.1136/bmj.281.6251.1309.
Serum samples from 201 drivers who presented at emergency departments within six hours after being injured in a road accident and 325 control drivers selected randomly at petrol stations were screened for drugs by combined thin-layer and gas chromatography. Blood alcohol concentrations were also measured, and a questionnaire on the subjects' state of health and use of drugs administered. At interview 30 patients (15%) and 44 controls (13%) said that they had taken drugs in the previous 24 hours. Four patients (2%) and six controls (2%) said that they had taken psychotropic drugs, but serum analysis detected psychotropic drugs in 10 patients (5%) and eight controls (2.5%). Diazepam was found in 16 of the 18 subjects in whom psychotropic drugs were detected. Alcohol was detected in 30 patients (15%) and three controls (1%). Drug use appeared to be somewhat lower in Finland than in other Western countries, and illness to be a more important traffic hazard than drugs in general. Interview was not a reliable method of establishing whether drivers had taken psychotropic drugs. Taking diazepam may increase the risk of being involved in a traffic accident, but alcohol was the most powerful risk factor.
对201名在道路交通事故受伤后6小时内前往急诊科的司机以及325名在加油站随机挑选的对照司机的血清样本,采用薄层色谱和气相色谱联用的方法进行药物筛查。同时测量血液酒精浓度,并就受试者的健康状况和用药情况进行问卷调查。在访谈中,30名患者(15%)和44名对照者(13%)表示他们在过去24小时内服用过药物。4名患者(2%)和6名对照者(2%)表示他们服用过精神药物,但血清分析在10名患者(5%)和8名对照者(2.5%)中检测到了精神药物。在检测出精神药物的18名受试者中,有16人检测出地西泮。在30名患者(15%)和3名对照者(1%)中检测到酒精。芬兰的药物使用情况似乎略低于其他西方国家,而且一般来说,疾病是比药物更重要的交通危险因素。访谈并非确定司机是否服用精神药物的可靠方法。服用地西泮可能会增加发生交通事故的风险,但酒精是最主要的危险因素。