Senba M, Watanabe M
Department of Pathology, Nagasaki University, Japan.
Zentralbl Pathol. 1991;137(5):402-4.
Ectopic production of human chorionic gonadotropin (HCG) in tumor cells is an uncommon phenomenon that has rarely been documented. The immunoperoxidase method was used to demonstrate the presence of beta-subunit of HCG in malignant lymphoma cases, using paraffin-embedded sections of lymph nodes. 3 of 11 cases of malignant lymphoma (27%) were positively stained with beta-subunit of HCG. All positive cases were T-cell type malignant lymphomas, but all adult T-cell leukemia lymphoma cases did not react with HCG. All B-cell type malignant lymphoma cases were not stained by HCG. Hence, this evidence suggested that beta-subunit of HCG may be useful as a tumor marker in certain malignant lymphoma patients. To the best of our knowledge, production of beta-subunit of HCG in the cytoplasm of malignant lymphoma cells has not been reported.
肿瘤细胞异位产生人绒毛膜促性腺激素（HCG）是一种罕见现象，鲜有文献记载。本研究采用免疫过氧化物酶法，利用淋巴结石蜡包埋切片，检测恶性淋巴瘤病例中HCGβ亚基的存在情况。11例恶性淋巴瘤病例中有3例（27%）HCGβ亚基呈阳性染色。所有阳性病例均为T细胞型恶性淋巴瘤，但所有成人T细胞白血病淋巴瘤病例均未与HCG发生反应。所有B细胞型恶性淋巴瘤病例均未被HCG染色。因此，这一证据表明，HCGβ亚基可能作为某些恶性淋巴瘤患者的肿瘤标志物。据我们所知，尚未有恶性淋巴瘤细胞胞质中产生HCGβ亚基的报道。
