Oliver R T, Stephenson C, Collino C E, Parkinson M C
London Hospital Medical College, Whitechapel, UK.
Mol Biother. 1988;1(1):43-5.
Immunocytochemical screening of bladder tumors with an antibody to beta-human chorionic gonadotrophin (hCG) demonstrates a correlation with malignant behavior in that 0 of 20 G1M0, 5 of 20 G3M0, and 11 of 20 G2/3M + showed strong staining, while only 2/20 G3 Ca prostate and 0/18 renal cell carcinoma showed weak staining. There was a suggestion that hCG positive bladder cancer responded less well to chemotherapy (1 of 12 hCG positive and 6 of 13 hCG negative patients achieved a complete or partial response) and also patients whose tumors showed strong hCG staining did less well after radiotherapy, though paradoxically patients showing only occasional stained cells did better than patients whose tumor showed no staining. The possible significance of these observations in relation to recent observations on the mechanisms of trophoblast escape from immune surveillance is discussed.
用抗β-人绒毛膜促性腺激素（hCG）抗体对膀胱肿瘤进行免疫细胞化学筛查，结果显示其与恶性行为相关，具体如下：20例G1M0肿瘤中0例呈强染色，20例G3M0肿瘤中有5例呈强染色，20例G2/3M +肿瘤中有11例呈强染色，而20例G3期前列腺癌中只有2例呈弱染色，18例肾细胞癌中0例呈弱染色。有迹象表明，hCG阳性的膀胱癌对化疗反应较差（12例hCG阳性患者中有1例、13例hCG阴性患者中有6例实现了完全或部分缓解），而且肿瘤呈hCG强染色的患者放疗后效果也较差，不过矛盾的是，仅偶尔有染色细胞的患者比肿瘤无染色的患者效果更好。本文讨论了这些观察结果与近期关于滋养层细胞逃避免疫监视机制的观察结果可能具有的相关性。
