Ramadan M, el-Aziz A A, Helmy M, Saleh L, Tamara F
Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University.
J Egypt Public Health Assoc. 1998;73(1-2):31-40.
This work was done to assess the relation between HPV B19 infection and arthropathies in Egyptian adults cases. For this purpose 40 rheumatoid arthritis (RA) cases, 10 osteoarthritis cases and 10 systemic lupus erythematosus (SLE) cases were selected to represent different types of arthropathies. The selection of cases was based on clinical diagnosis and laboratory tests (ESR, Hb level, Rose waller, detection of antinuclear antibodies and detection of hidden rheumatoid factor). HPV B19 IgM and IgG were searched for by ELISA test in their sera as indicator of the state of HPV B19 infection. A control group was also included in this study, as 30 healthy persons with no previous complaint of rheumatic symptoms. HPV B19 IgM was detected in 60% of patients with RA, 40% of osteoarthritis cases and None of the SLE cases. Positive cases were more among females with long duration of illness affecting both big and small joints. These results indicated a possible causal association between acute HPV B19 and arthropathy. As regards HPV B19 IgG, it was detected in 57% of RA cases, 60% of osteoarthritis cases and 40% of SLE. The difference in IgG was statistically insignificant from the control group (46.7%). The presence of HPV B19 IgG antibodies indicates previous exposure to the virus but does not indicate its time. Detection of HPV B19 IgM or rising titer of HPV B19 IgG may lead to early diagnosis of HPV B19 arthropathies.
本研究旨在评估埃及成年病例中B19型人乳头瘤病毒（HPV B19）感染与关节病之间的关系。为此，选取了40例类风湿性关节炎（RA）病例、10例骨关节炎病例和10例系统性红斑狼疮（SLE）病例，以代表不同类型的关节病。病例的选择基于临床诊断和实验室检查（红细胞沉降率、血红蛋白水平、罗斯-瓦勒试验、抗核抗体检测以及隐匿性类风湿因子检测）。通过酶联免疫吸附测定（ELISA）试验检测其血清中的HPV B19 IgM和IgG，作为HPV B19感染状态的指标。本研究还纳入了一个对照组，由30名既往无风湿症状主诉的健康人组成。在RA患者中，60%检测到HPV B19 IgM，骨关节炎病例中有40%检测到，而SLE病例中均未检测到。阳性病例在病程较长、大小关节均受累的女性中更多。这些结果表明急性HPV B19感染与关节病之间可能存在因果关联。至于HPV B19 IgG，在57%的RA病例、60%的骨关节炎病例和40%的SLE病例中检测到。与对照组（46.7%）相比，IgG的差异无统计学意义。HPV B19 IgG抗体的存在表明既往接触过该病毒，但不能表明接触时间。检测HPV B19 IgM或HPV B19 IgG滴度升高可能有助于HPV B19关节病的早期诊断。
