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墨西哥患有系统性红斑狼疮的玛雅女性中细小病毒B19感染的血清学和分子分析

Serological and molecular analysis of parvovirus B19 infection in Mayan women with systemic lupus erythematosus in Mexico.

作者信息

Valencia Pacheco Guillermo, Nakazawa Ueji Yumi E, Rodríguez Dzul Edwin A, Angulo Ramírez Angélica V, López Villanueva Ricardo F, Quintal Ortiz Irma G, Rosado Paredes Elsy P

机构信息

Laboratorio de Hematología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán. Mérida, Yucatán, México.

Hospital General Agustín O'Horán. Mérida, Yucatán, México.

出版信息

Colomb Med (Cali). 2017 Sep 30;48(3):105-112. doi: 10.25100/cm.v48i3.2981.

DOI:10.25100/cm.v48i3.2981
PMID:29213152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5687861/
Abstract

BACKGROUND

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that mainly affects women, characterized by the production of autoantibodies. Its causal agent is unknown, but the combination of environmental, hormonal and genetic factors may favor the development of the disease. Parvovirus B19 has been associated with the development of SLE, since it induces the production of anti-single stranded DNA antibodies. It is unknown whether PV-B19 infection is an environmental factor that trigger or reactivate SLE in the Mexican Mayan population.

AIM

A preliminary serological and molecular study of PV-B19 infection in Mayan women with established SLE was done.

METHODS

IgG and IgM anti PV-B19 were evaluated in 66 SLE patients and 66 control subjects, all women of Mayan origin. Viral DNA and viral load were analyzed by qPCR.

RESULTS

Insignificant levels of IgM were observed in 14.3% (4/28) of the patients and 11.4% (4/35) of control subjects. IgG was detected in 82.1% (23/28) of the patients and 82.9% (29/35) of control subjects, but were significantly higher in patients. Viral DNA was found in 86.0% (57/66) of the patients and 81.0% (54/66) of control subjects. Viral load, quantified in 28/66 patients and 31/66 controls which were positive for IgM and IgG, was significantly higher in controls.

CONCLUSION

The high prevalence of PV-B19 in Yucatan, and the presence of IgM, IgG, and viral load in Mayan women with established SLE suggest that PV-B19 infection could be an environmental factor to trigger or reactivate SLE.

摘要

背景

系统性红斑狼疮（SLE）是一种主要影响女性的系统性自身免疫性疾病，其特征为自身抗体的产生。病因不明，但环境、激素和遗传因素的综合作用可能促使该病的发展。细小病毒B19与SLE的发生有关，因为它可诱导抗单链DNA抗体的产生。在墨西哥玛雅人群中，尚不清楚B19病毒感染是否为触发或重新激活SLE的环境因素。

目的

对确诊为SLE的玛雅女性进行B19病毒感染的初步血清学和分子研究。

方法

对66例SLE患者和66例对照者（均为玛雅裔女性）进行了抗B19病毒IgG和IgM检测。通过定量聚合酶链反应（qPCR）分析病毒DNA和病毒载量。

结果

14.3%（4/28）的患者和11.4%（4/35）的对照者中观察到IgM水平无显著差异。82.1%（23/28）的患者和82.9%（29/35）的对照者检测到IgG，但患者中的IgG水平显著更高。86.0%（57/66）的患者和81.0%（54/66）的对照者中发现病毒DNA。对28/66例IgM和IgG呈阳性的患者及31/66例对照者进行病毒载量定量分析，结果显示对照者中的病毒载量显著更高。

结论

尤卡坦半岛B19病毒的高流行率，以及确诊为SLE的玛雅女性中存在IgM、IgG和病毒载量，提示B19病毒感染可能是触发或重新激活SLE的环境因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/b798c7116e95/1657-9534-cm-48-03-00105-gf12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/631bded57852/1657-9534-cm-48-03-00105-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/b798c7116e95/1657-9534-cm-48-03-00105-gf12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/e4ddfb1f16ac/1657-9534-cm-48-03-00105-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/3f109726ee10/1657-9534-cm-48-03-00105-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/c61db369382d/1657-9534-cm-48-03-00105-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/6d77e72e43b0/1657-9534-cm-48-03-00105-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/2f3b16c46eb0/1657-9534-cm-48-03-00105-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/b798c7116e95/1657-9534-cm-48-03-00105-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/62c4abbd6f94/1657-9534-cm-48-03-00105-gf7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/ee1800717a74/1657-9534-cm-48-03-00105-gf8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/c61db369382d/1657-9534-cm-48-03-00105-gf9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/c4c40728ca8a/1657-9534-cm-48-03-00105-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/631bded57852/1657-9534-cm-48-03-00105-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d105/5687861/b798c7116e95/1657-9534-cm-48-03-00105-gf12.jpg

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本文引用的文献

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2
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Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1467-75. doi: 10.1007/s10096-014-2098-7. Epub 2014 Apr 9.
3
Estimating the risk of parvovirus B19 infection in blood donors and pregnant women in Japan.评估日本献血者和孕妇感染细小病毒B19的风险。
PLoS One. 2014 Mar 21;9(3):e92519. doi: 10.1371/journal.pone.0092519. eCollection 2014.
4
Seroprevalence of human parvovirus B19 in healthy blood donors.健康献血者中B19型人细小病毒的血清流行率。
Med J Armed Forces India. 2013 Jul;69(3):268-72. doi: 10.1016/j.mjafi.2012.11.009. Epub 2013 Feb 23.
5
Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies.系统性红斑狼疮患者的感染风险：易感因素与预防策略。
Lupus. 2013 Oct;22(12):1286-94. doi: 10.1177/0961203313493032.
6
The cryptic interplay between systemic lupus erythematosus and infections.系统性红斑狼疮与感染之间的复杂相互作用。
Autoimmun Rev. 2014 Feb;13(2):96-102. doi: 10.1016/j.autrev.2013.09.004. Epub 2013 Sep 17.
7
Keeping pace with parvovirus B19 genetic variability: a multiplex genotype-specific quantitative PCR assay.紧跟细小病毒 B19 遗传变异步伐：多重基因型特异性定量 PCR 检测方法。
J Clin Microbiol. 2013 Nov;51(11):3753-9. doi: 10.1128/JCM.01970-13. Epub 2013 Sep 4.
8
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