Silver W L, Farley L G, Finger T E
Department of Biology, Wake Forest University, Winston-Salem, NC 27109.
Brain Res. 1991 Oct 11;561(2):212-6. doi: 10.1016/0006-8993(91)91597-t.
Trigeminal nerve fibers in the nasal cavity respond to a variety of volatile chemical stimuli. Some of these trigeminal nerve fibers have been suggested to be capsaicin-sensitive and thus belong to a class of pain receptor rather than constituting a separate class of chemoreceptor. Our current results confirm this suggestion. Trigeminal nerve responses to volatile chemical stimuli were eliminated in rats which were injected with capsaicin on the second day of life. Animals whose nerves were unresponsive to chemical stimuli also exhibited a loss of intraepithelial peptide-immunoreactive fibers in their nasal cavities. The results of this study suggest that trigeminal nerve fibers in the nasal cavity which respond to chemical stimuli may be polymodal nociceptors which contain substance P, calcitonin gene-related peptide, or perhaps other neuropeptides.
鼻腔中的三叉神经纤维对多种挥发性化学刺激有反应。有人提出，这些三叉神经纤维中的一些对辣椒素敏感，因此属于痛觉感受器类别，而非构成一类独立的化学感受器。我们目前的结果证实了这一观点。在出生第二天注射辣椒素的大鼠中，三叉神经对挥发性化学刺激的反应消失了。其神经对化学刺激无反应的动物，鼻腔内上皮肽免疫反应性纤维也出现缺失。本研究结果表明，鼻腔中对化学刺激有反应的三叉神经纤维可能是含有P物质、降钙素基因相关肽或其他可能的神经肽的多模式伤害感受器。
