Lundblad L, Saria A, Lundberg J M, Anggård A
Acta Otolaryngol. 1983 Nov-Dec;96(5-6):479-84. doi: 10.3109/00016488309132734.
Electrical stimulation of the maxillary branches of the trigeminal nerve induced an increase in vascular permeability to macromolecules and an interstitial edema in the nasal mucosa of the rat, as indicated by extravasation of Evans blue. In animals that had been treated neonatally with capsaicin, the effect of trigeminal nerve stimulation was abolished. Local application of capsaicin or substance P (SP) also induced a significant Evans blue extravasation in the nasal mucosa. In capsaicin-pretreated animals the effect of SP was still present, while the permeability increase induced by capsaicin was abolished. In conclusion, chemogenic irritation of the nasal mucosa by capsaicin induces edema probably via a local axon reflex inducing release of SP. Capsaicin-sensitive SP-containing afferents in the nasal mucosa may also be involved in the pathogenesis of nasal congestion seen in various types of rhinitis.
三叉神经上颌支的电刺激可导致大鼠鼻粘膜对大分子的血管通透性增加和间质水肿，伊文思蓝外渗表明了这一点。在新生期用辣椒素处理过的动物中，三叉神经刺激的作用被消除。局部应用辣椒素或P物质（SP）也可导致鼻粘膜出现明显的伊文思蓝外渗。在经辣椒素预处理的动物中，SP的作用仍然存在，而辣椒素诱导的通透性增加则被消除。总之，辣椒素对鼻粘膜的化学性刺激可能通过局部轴突反射诱导SP释放而导致水肿。鼻粘膜中对辣椒素敏感的含SP传入神经也可能参与各种类型鼻炎中出现的鼻充血的发病机制。
