Samani N J
Department of Medicine, University of Leicester, England.
J Cardiovasc Pharmacol. 1991;18 Suppl 2:S1-6.
In the last decade, nucleic acid sequences coding for all three components of the renin-angiotensin cascade have been cloned. This has led to increased understanding of the transcriptional and translational regulation of renin, angiotensinogen, and angiotensin-converting enzyme (ACE). This review discusses the impact of the availability of these clones in three clinically relevant areas--the role of the renin-angiotensin system in hypertension, the role of tissue renin-angiotensin systems, and the development of renin inhibitors.
在过去十年中，编码肾素 - 血管紧张素级联反应所有三个组分的核酸序列已被克隆。这使得人们对肾素、血管紧张素原和血管紧张素转换酶（ACE）的转录和翻译调控有了更多了解。本综述讨论了这些克隆在三个临床相关领域的影响——肾素 - 血管紧张素系统在高血压中的作用、组织肾素 - 血管紧张素系统的作用以及肾素抑制剂的开发。
