经支气管细针穿刺细胞学检查在纵隔/肺门结节病诊断中的应用
Transbronchial fine needle aspiration cytology in the diagnosis of mediastinal/hilar sarcoidosis.
作者信息
Smojver-Jezek S, Peros-Golubicić T, Tekavec-Trkanjec J, Mazuranić I, Alilović M
机构信息
Department of Cytology, University Hospital for Lung Disease Jordanovac, Zagreb, Croatia.
出版信息
Cytopathology. 2007 Feb;18(1):3-7. doi: 10.1111/j.1365-2303.2006.00336.x.
OBJECTIVE
The diagnostic value of transbronchial/transtracheal fine needle aspiration (TBFNA) cytology in the patients with mediastinal and/or hilar lymphadenopathy has been investigated.
METHOD
Out of 116 patients with mediastinal/hilar lymphadenopathy, the diagnosis of sarcoidosis was established in 88 (75.9%). One hundred and seventy-one TBFNAs from different lymph node stations were performed using a cytological 26-gauge needle. Adequate lymph node samples were obtained in 157 of 171 (91.8%) TBFNA and 14 of 171 (8.2%) TBFNA samples were inadequate.
RESULTS
Cytological findings consistent with sarcoidosis were found in 79 of 88 (89.77%) patients and 133 of 157 (84.71%) samples. The sensitivity of TBFNA cytology in sarcoidosis presenting as mediastinal/hilar lymphadenopathy was 78.7%, specificity 92.3%.
CONCLUSIONS
Overall diagnostic accuracy of TBFNA cytology in the diagnosis of sarcoidosis was 86.2%, and cytological findings consistent with sarcoidosis were the only morphological diagnosis of sarcoidosis in 63.6% of patients.
目的
研究经支气管/经气管细针穿刺抽吸（TBFNA）细胞学检查对纵隔和/或肺门淋巴结肿大患者的诊断价值。
方法
116例纵隔/肺门淋巴结肿大患者中，88例（75.9%）确诊为结节病。使用26号细胞学穿刺针从不同淋巴结部位进行了171次TBFNA检查。171次TBFNA检查中，157次（91.8%）获得了足够的淋巴结样本，171次（8.2%）样本不足。
结果
88例患者中的79例（89.77%）以及157份样本中的133份（84.71%）细胞学检查结果符合结节病。TBFNA细胞学检查对表现为纵隔/肺门淋巴结肿大的结节病的敏感性为78.7%，特异性为92.3%。
结论
TBFNA细胞学检查对结节病诊断的总体诊断准确率为86.2%，63.6%的患者中符合结节病的细胞学检查结果是结节病的唯一形态学诊断。
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