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卡帕多西亚的间皮瘤流行:科学进展与意外的社会后果。

A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes.

作者信息

Carbone Michele, Emri Salih, Dogan A Umran, Steele Ian, Tuncer Murat, Pass Harvey I, Baris Y Izzettin

机构信息

Cancer Research Center of Hawaii, Thoracic Oncology Program, Honolulu, Hawaii 96816, USA.

出版信息

Nat Rev Cancer. 2007 Feb;7(2):147-54. doi: 10.1038/nrc2068.

DOI:10.1038/nrc2068
PMID:17251920
Abstract

In Cappadocia, Turkey, an unprecedented mesothelioma epidemic causes 50% of all deaths in three small villages. Initially linked solely to the exposure to a fibrous mineral, erionite, recent studies by scientists from Turkey and the United States have shown that erionite causes mesothelioma mostly in families that are genetically predisposed to mineral fibre carcinogenesis. This manuscript reports, through the eyes of one of the researchers, the resulting scientific advances that have come from these studies and the social improvements that were brought about by both the scientists and members of the Turkish Government.

摘要

在土耳其的卡帕多西亚,一场史无前例的间皮瘤疫情导致三个小村庄50%的人死亡。最初人们认为这仅仅与接触一种纤维状矿物质——毛沸石有关,但土耳其和美国科学家最近的研究表明,毛沸石主要在那些对矿物纤维致癌作用具有遗传易感性的家庭中引发间皮瘤。这份手稿通过一位研究人员的视角,报道了这些研究带来的科学进展以及科学家和土耳其政府成员所促成的社会进步。

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