Metintas Muzaffer, Hillerdal Gunnar, Metintas Selma, Dumortier Pascal
Department of Chest Diseases, Eskisehir Osmangazi University, Medical Faculty, Eskisehir, Turkey.
Arch Environ Occup Health. 2010 Apr-Jun;65(2):86-93. doi: 10.1080/19338240903390305.
The village of Karain, Turkey, has the world's highest prevalence rate of malignant mesothelioma (MM). Environmental exposure to erionite is thought to cause the disease. However, it has also been suggested that the disease is mainly genetic. Residents in Karain village were traced from 1990 to 2006. Mineral samples were obtained from stones used in construction of their houses and any fibers present were identified. All women who had moved to the village as brides were traced and their cause of death determined. MM was the cause of death in 52 of 322 villagers, representing 50.5% of all deaths. Only 2 of 8 types of stones used in construction contained erionite, and these stones had been used almost exclusively in the mid-sections of the village, where MM was common. In houses not containing erionite, no cases of MM were observed. Sixty-four women came as brides to Karain from villages where erionite or asbestos is not found. Of the 16 women who have died, 11 (69%) died from MM. The extreme risk of MM in Karain is due to indoor exposure to erionite. The effect of genetic factors on mesothelioma development cannot be evaluated in this study, but is likely to be minor.
土耳其的卡赖恩村是世界上恶性间皮瘤（MM）患病率最高的地方。环境中接触毛沸石被认为是导致该病的原因。然而，也有人认为该病主要是由遗传因素引起的。对卡赖恩村的居民从1990年至2006年进行了追踪。从他们房屋建造所用的石头中获取矿物样本，并鉴定其中存在的任何纤维。所有作为新娘嫁到该村的女性都被追踪，并确定其死因。在322名村民中，有52人死于MM，占所有死亡人数的50.5%。建造房屋所用的8种石头中只有2种含有毛沸石，而且这些石头几乎只用于村子中部，而MM在该区域很常见。在不含有毛沸石的房屋中，未观察到MM病例。64名女性作为新娘从没有毛沸石或石棉的村庄嫁到卡赖恩。在已去世的16名女性中，有11人（69%）死于MM。卡赖恩村MM的极高风险是由于室内接触毛沸石所致。本研究无法评估遗传因素对间皮瘤发展的影响，但可能影响较小。
