急性缺血性中风患者的低白蛋白血症：发生率及其相关因素

Hypoalbuminemia in acute ischemic stroke patients: frequency and correlates.

作者信息

Dziedzic T, Pera J, Slowik A, Gryz-Kurek E A, Szczudlik A

机构信息

Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland.

出版信息

Eur J Clin Nutr. 2007 Nov;61(11):1318-22. doi: 10.1038/sj.ejcn.1602643. Epub 2007 Jan 24.

DOI:10.1038/sj.ejcn.1602643

PMID:17251921

Abstract

OBJECTIVE

Hypoalbuminemia in acute stroke patients is associated with increased mortality and morbidity. The aim of our study was to determine the frequency and correlates of hypoalbuminemia in unselected cohort of patients with acute cerebral infarction.

DESIGN

Prospective study.

SETTING

University hospital.

SUBJECTS

Seven hundred and five consecutive ischemic stroke patients.

METHODS

Albumin and other serum protein fractions were measured within 36 h after stroke using electrophoresis.

RESULTS

Hypoalbuminemia defined as serum albumin level <35 g/l was found in 45.5% of patients. Serum albumin level correlates significantly with age (r=-0.13, P<0.01), Scandinavian Stroke Scale score (r=0.14, P<0.01), body temperature on admission (r=0.14, P<0.01), leukocyte count (r=-0.17, P<0.01), fasting glucose (r=-0.16, P<0.01), total cholesterol (r=0.14, P<0.01), alpha1-globulin (r=-0.48, P<0.01), alpha2-globulin (r=-0.49, P<0.01), beta-globulin (r=-0.26, P<0.01) and gamma-globulin (r=-0.35, P<0.01).

CONCLUSIONS

Hypoalbuminemia is a frequent finding in acute stroke patients and it is associated with more severe stroke and pro-inflammatory pattern of serum protein electrophoresis.

摘要

目的

急性脑卒中患者的低白蛋白血症与死亡率和发病率增加相关。我们研究的目的是确定急性脑梗死患者未选择队列中低白蛋白血症的发生率及其相关因素。

设计

前瞻性研究。

地点

大学医院。

研究对象

705例连续的缺血性脑卒中患者。

方法

卒中后36小时内采用电泳法测定白蛋白及其他血清蛋白组分。

结果

45.5%的患者存在血清白蛋白水平<35 g/l的低白蛋白血症。血清白蛋白水平与年龄（r=-0.13，P<0.01）、斯堪的纳维亚卒中量表评分（r=0.14，P<0.01）、入院时体温（r=0.14，P<0.01）、白细胞计数（r=-0.17，P<0.01）、空腹血糖（r=-0.16，P<0.01）、总胆固醇（r=0.14，P<0.01）、α1球蛋白（r=-0.48，P<0.01）、α2球蛋白（r=-0.49，P<0.01）、β球蛋白（r=-0.26，P<0.01）和γ球蛋白（r=-0.35，P<0.01）显著相关。