Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Sci Rep. 2022 Jun 30;12(1):11087. doi: 10.1038/s41598-022-15397-y.
This study aimed to investigate the prevalence of and risk factors for multidrug-resistant organism (MDRO) infection in the rehabilitation ward of a general hospital in Southwest China. We analyzed rehabilitation patients with nosocomial infections caused by MDROs from June 2016 to June 2020. MDRO infection pathogens and associated antibiotic resistance were calculated. Possible risk factors for MDRO-related infection in the neurorehabilitation ward were analyzed using chi-square, and logistic regression. A total of 112 strains of MDRO were found positive from 96 patients. The MDRO test-positive rate was 16.70% (96/575). Ninety-five MDRO strains were detected in sputum, of which 84.82% (95/112) were gram-negative bacteria. Acinetobacter baumannii (A. Baumannii), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumonia (K. pneumonia) were the most frequently isolated MDRO strains. The logistic regression model and multifactorial analysis showed that long-term (≥ 7 days) antibiotic use (OR 6.901), history of tracheotomy (OR 4.458), and a low albumin level (< 40 g/L) (OR 2.749) were independent risk factors for the development of MDRO infection in patients in the rehabilitation ward (all P < 0.05). Gram-negative MRDOs were dominant in rehabilitation ward patients. Low albumin, history of a tracheostomy, and long-term use of antibiotics were independent risk factors for MRDO infection and are worthy of attention.
本研究旨在调查中国西南部一家综合医院康复病房多药耐药菌（MDRO）感染的流行情况和危险因素。我们分析了 2016 年 6 月至 2020 年 6 月期间因 MDRO 引起医院感染的康复患者。计算了 MDRO 感染病原体及其相关抗生素耐药性。使用卡方检验和逻辑回归分析神经康复病房 MDRO 相关感染的可能危险因素。从 96 例患者中发现 112 株 MDRO 阳性。MDRO 检测阳性率为 16.70%（96/575）。在 95 株 MDRO 菌株中，有 84.82%（95/112）为革兰氏阴性菌。鲍曼不动杆菌（A. Baumannii）、铜绿假单胞菌（P. aeruginosa）和肺炎克雷伯菌（K. pneumonia）是最常分离到的 MDRO 菌株。逻辑回归模型和多因素分析显示，长期（≥7 天）使用抗生素（OR 6.901）、有气管切开史（OR 4.458）和低白蛋白水平（<40 g/L）（OR 2.749）是康复病房患者发生 MDRO 感染的独立危险因素（均 P<0.05）。康复病房患者中以革兰氏阴性 MDRO 为主。低白蛋白血症、气管切开史和长期使用抗生素是 MDRO 感染的独立危险因素，值得关注。
