Pekarek V, Srinivas S, Eskdale J, Gallagher G
HUMIGEN, The Institute for Genetic Immunology, Hamilton, NJ 08690-3303, USA.
Genes Immun. 2007 Mar;8(2):177-80. doi: 10.1038/sj.gene.6364372. Epub 2007 Jan 25.
Interferon lambda-1 (IFN-lambda1), the prototype Type-III interferon, has antiviral functions similar to those of the Type-I interferons, IFN-alpha and IFN-beta. However, IFN-lambda1 is capable of signaling through almost all STAT molecules and so it is possible that it may have novel immunoregulatory functions in addition to antiviral ones. From a range of chemokines tested, IFN-lambda1 elevated mRNA levels of only 'Monokine induced by IFN-gamma' (MIG/CXCL9), 'IFN-gamma inducible protein-10' (IP-10/CXCL10) and 'IFN-gamma inducible T-cell alpha chemoattractant' (I-TAC/CXCL11) from human peripheral blood mononuclear cells. As their names suggest, these chemokines are also induced by IFN-gamma, the only member of the Type-II interferon family. This action of IFN-lambda1 did not depend on intermediate induction of IFN-gamma and is therefore, likely to be independent of IFN-gamma. Further, our results suggest that donors responded to IFN-lambda1 stimulation either 'early' or 'late'. Overall the action of IFN-lambda1 was similar to that previously reported for IFN-gamma and may invite more detailed investigation of the role of IFN-lambda1 at the innate/adaptive interface.
干扰素λ-1（IFN-λ1）是III型干扰素的原型，具有与I型干扰素IFN-α和IFN-β相似的抗病毒功能。然而，IFN-λ1能够通过几乎所有的信号转导和转录激活因子（STAT）分子进行信号传导，因此除了抗病毒功能外，它可能还具有新的免疫调节功能。在所测试的一系列趋化因子中，IFN-λ1仅提高了人外周血单个核细胞中“γ干扰素诱导的单核因子”（MIG/CXCL9）、“γ干扰素诱导蛋白10”（IP-10/CXCL10）和“γ干扰素诱导的T细胞α趋化因子”（I-TAC/CXCL11）的mRNA水平。顾名思义，这些趋化因子也由II型干扰素家族的唯一成员γ干扰素诱导产生。IFN-λ1的这一作用不依赖于γ干扰素的中间诱导，因此可能与γ干扰素无关。此外，我们的结果表明，供体对IFN-λ1刺激的反应分为“早期”或“晚期”。总体而言，IFN-λ1的作用与先前报道的γ干扰素的作用相似，可能会引发对IFN-λ1在天然免疫/适应性免疫界面中作用的更详细研究。
