Cinier Justine, Hubert Margaux, Besson Laurie, Di Roio Anthony, Rodriguez Céline, Lombardi Vincent, Caux Christophe, Ménétrier-Caux Christine
University of Lyon, Claude Bernard Lyon 1 University, INSERM U-1052, CNRS 5286 Centre Léon Bérard, Cancer Research Center of Lyon (CRCL), 69008 Lyon, France.
Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Cancers (Basel). 2021 Apr 13;13(8):1850. doi: 10.3390/cancers13081850.
Regulatory T cells (Tregs) are present in a large majority of solid tumors and are mainly associated with a poor prognosis, as their major function is to inhibit the antitumor immune response contributing to immunosuppression. In this review, we will investigate the mechanisms involved in the recruitment, amplification and stability of Tregs in the tumor microenvironment (TME). We will also review the strategies currently developed to inhibit Tregs' deleterious impact in the TME by either inhibiting their recruitment, blocking their expansion, favoring their plastic transformation into other CD4 T-cell subsets, blocking their suppressive function or depleting them specifically in the TME to avoid severe deleterious effects associated with Treg neutralization/depletion in the periphery and normal tissues.
调节性T细胞（Tregs）在绝大多数实体瘤中都存在，并且主要与预后不良相关，因为它们的主要功能是抑制抗肿瘤免疫反应，从而导致免疫抑制。在本综述中，我们将研究肿瘤微环境（TME）中Tregs的募集、扩增和稳定性所涉及的机制。我们还将综述目前开发的策略，这些策略通过抑制Tregs的募集、阻止其扩增、促进其向其他CD4 T细胞亚群的可塑性转变、阻断其抑制功能或在TME中特异性清除它们，来抑制Tregs在TME中的有害影响，以避免与外周和正常组织中Treg中和/清除相关的严重有害影响。
