光不稳定型烟酰胺腺嘌呤二核苷酸磷酸（NAADP+）的化学酶法合成及生物学评价
Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).
作者信息
Parkesh Raman, Vasudevan Sridhar R, Berry Alexandra, Galione Antony, Dowden James, Churchill Grant C
机构信息
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
出版信息
Org Biomol Chem. 2007 Feb 7;5(3):441-3. doi: 10.1039/b617344f. Epub 2006 Dec 11.
Abstract
A chemo-enzymatic synthesis of novel caged NAADP+ without the formation of multiple cage compounds has been achieved. The biological activity of the caged NAADP+ was demonstrated by its fast uncaging in intact sea-urchin eggs.
摘要
已实现了新型笼形NAADP⁺的化学酶法合成，且未形成多种笼形化合物。笼形NAADP⁺在完整海胆卵中的快速解笼证明了其生物活性。
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Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain.新型钙离子动员信使烟酰胺腺嘌呤二核苷酸磷酸的结合位点在大脑中的广泛分布。
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