Picano Eugenio, Lombardi Massimo, Neglia Danilo, Lazzeri Mauro
Responsabile Laboratorio Ecocardiografia dell'Istituto di Fisiologia Clinica, CNR, Pisa.
Recenti Prog Med. 2006 Nov;97(11):652-62.
Every year, 5 billion imaging testing are performed worldwide, and about 1 out of 2 are cardiovascular examinations. According to recent estimates, 30 to 50% of all examinations are partially or totally inappropriate. This represents a potential damage for patient undergoing imaging (who takes the acute risks of a stress procedure and/or a contrast study without a commensurable benefit), an exorbitant cost for the society and an excessive delay in the waiting lists for other patients needing the examination. Economic induction, medico-legal concern, and specialist guidelines, which do not quantitate the potential benefits against the risks of a given procedure, boost inappropriateness of all imaging techniques. In case of ionizing tests, the reduction of useless imaging testing would improve the quality of care also through abatement of long-term risks, which are linked to the dose employed. The radiation dose equivalent of common cardiological imaging examinations corresponds to more than 1000 chest x rays for a thallium scan and to more than 500 chest x-rays for a multislice computed tomography. Although a direct evaluation of incidence of cancer in patients submitted to these procedures is not available, the estimated risk (often ignored by cardiologists) of cancer according to the latest 2005 Biological Effects of Ionizing Radiation Committee VII is about one in 500 exposed patients for a Thallium scintigraphy scan, and one in 750 for a CT scan. Such a risk is probably not acceptable when a scintigraphic or radiological procedure is applied for mass screening (when the risk side of the risk-benefit balance is not considered) or when a similar information can be obtained by other means. By contrast, it is fully acceptable in appropriately selected groups as a filter to more invasive, risky and costly procedures (for instance, coronary angiography and anatomy-driven revascularization). At this point, the cardiological community, that faces the reality of limited resources, should do every effort in order to minimize inappropriate testing, since they induce an exorbitant increase in health care costs with no improvement, and possibly with a reduction in care quality.
每年,全球进行50亿次影像检查,其中约二分之一是心血管检查。根据最近的估计,所有检查中有30%至50%部分或完全不恰当。这对接受影像检查的患者构成潜在损害(他们承受着应激检查和/或造影研究的急性风险,却未获得相应益处),给社会带来过高成本,还导致其他需要检查的患者候诊名单过度延迟。经济诱因、医疗法律问题以及专业指南(这些指南并未对特定检查的潜在益处与风险进行量化),加剧了所有影像技术使用的不恰当性。对于电离辐射检查而言,减少不必要的影像检查还可通过降低与所使用剂量相关的长期风险来提高医疗质量。普通心脏影像检查的辐射剂量当量,铊扫描相当于超过1000次胸部X光,多层螺旋计算机断层扫描相当于超过500次胸部X光。尽管目前尚无对接受这些检查的患者癌症发病率的直接评估,但根据2005年电离辐射生物学效应委员会VII的最新估计,铊闪烁扫描检查的暴露患者中患癌风险约为五百分之一,CT扫描为七百分之一。当将闪烁扫描或放射学检查用于大规模筛查(未考虑风险效益平衡中的风险方面)或可通过其他方式获取类似信息时,这样的风险可能无法接受。相比之下,在经过适当选择的群体中,作为更具侵入性、风险更高且成本更高的检查(如冠状动脉造影和解剖学驱动的血运重建)的筛选手段,该风险是完全可以接受的。此时,面对资源有限现实的心脏病学界应竭尽全力尽量减少不恰当检查,因为这些检查会导致医疗保健成本过度增加,却无改善,甚至可能降低医疗质量。