López-Pedrosa José M, Manzano Manuel, Baxter Jeffrey H, Rueda Ricardo
Strategic R&D, Abbott Nutrition International, Abbott Laboratories, Camino de Purchil 68, 18004 Granada, Spain.
Dig Dis Sci. 2007 Mar;52(3):650-8. doi: 10.1007/s10620-006-9500-y.
The goal of this study was to evaluate the preventive effect of free glutamine versus N-acetyl-L-glutamine, a liquid-stable source of glutamine, on gut damage induced by protein energy malnutrition in pigs. Healthy pigs (n = 6) were fed a liquid formula for 30 days. Three subgroups of malnourished pigs (n = 6) received daily 20% of the food intake recorded in control group, supplemented with calcium caseinate, glutamine, or N-acetyl-L-glutamine. Body weight was recorded, and small intestinal samples were evaluated for biochemical and immunologic parameters. Suppression in body weight gain was significantly lower in pigs fed with N-acetyl-L-glutamine than in the rest of malnourished pigs. Total number of lymphocytes, CD21+ B cells and CD4+ T cells in ileal Peyer patches were not significantly different in malnourished pigs fed with N-acetyl-L-glutamine and in healthy pigs. In conclusion, N-acetyl-L-glutamine has a moderate protective effect, partially preventing changes induced by protein energy malnutrition.
本研究的目的是评估游离谷氨酰胺与谷氨酰胺的液体稳定来源N-乙酰-L-谷氨酰胺对猪蛋白质能量营养不良所致肠道损伤的预防作用。将健康猪（n = 6）喂食液体配方饲料30天。三组营养不良猪（n = 6）每天摄入对照组记录食物摄入量的20%，并补充酪蛋白钙、谷氨酰胺或N-乙酰-L-谷氨酰胺。记录体重，并对小肠样本进行生化和免疫参数评估。喂食N-乙酰-L-谷氨酰胺的猪体重增加抑制明显低于其他营养不良猪。喂食N-乙酰-L-谷氨酰胺的营养不良猪与健康猪回肠派尔集合淋巴结中的淋巴细胞总数、CD21+B细胞和CD4+T细胞无显著差异。总之，N-乙酰-L-谷氨酰胺具有适度的保护作用，部分预防蛋白质能量营养不良引起的变化。
