从植物到线虫的RNA干扰

RNAi from plants to nematodes.

作者信息

Gheysen Godelieve, Vanholme Bartel

机构信息

Department of Molecular Biotechnology, Ghent University, Coupure links 653, 9000 Ghent, Belgium.

出版信息

Trends Biotechnol. 2007 Mar;25(3):89-92. doi: 10.1016/j.tibtech.2007.01.007. Epub 2007 Jan 24.

DOI:10.1016/j.tibtech.2007.01.007

PMID:17254655

Abstract

Coincident with the award of the Nobel Prize for Medicine in 2006 to Fire and Mello for their discovery of RNAi, plant scientists have succeeded in using RNAi-based techniques to control nematodes, a hitherto unmanageable plant parasite. Recent work has demonstrated that the expression in a host plant of double-stranded RNA targeting housekeeping or parasitism genes in the root-knot nematode resulted in resistance to nematode infection.

摘要

2006年，Fire和Mello因发现RNA干扰而获得诺贝尔医学奖，与此同时，植物科学家成功地利用基于RNA干扰的技术来控制线虫，这是一种迄今为止难以对付的植物寄生虫。最近的研究表明，在宿主植物中表达靶向根结线虫管家基因或寄生基因的双链RNA，可使植物对线虫感染产生抗性。