Bourre Jean-Marie
INSERM U 705, CNRS UMR 7157, Universités Paris 7 et 5, Hôpital Fernand Widal, 200 rue du Faubourg Saint Denis, 75745 Paris cedex 10, France.
Biomed Pharmacother. 2007 Feb-Apr;61(2-3):105-12. doi: 10.1016/j.biopha.2006.09.015. Epub 2007 Jan 2.
This review details the specific needs of women for omega-3 fatty acids, including alpha linoleic acid (ALA) and the very long chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Omega-3 fatty acid (dietary or in capsules) ensures that a woman's adipose tissue contains a reserve of these fatty acids for the developing fetus and the breast-fed newborn infant. This ensures the optimal cerebral and cognitive development of the infant. The presence of large quantities of EPA and DHA in the diet slightly lengthens pregnancy, and improves its quality. Human milk contains both ALA and DHA, unlike that of other mammals. Conditions such as diabetes can alter the fatty acid profile of mother's milk, while certain diets, like those of vegetarians, vegans, or even macrobiotic diets, can have the same effect, if they do not include seafood. ALA, DHA and EPA, are important for preventing ischemic cardiovascular disease in women of all ages. Omega-3 fatty acids can help to prevent the development of certain cancers, particularly those of the breast and colon, and possibly of the uterus and the skin, and are likely to reduce the risk of postpartum depression, manic-depressive psychosis, dementias (Alzheimer's disease and others), hypertension, toxemia, diabetes and, to a certain extend, age-related macular degeneration. Omega-3 fatty acids could play a positive role in the prevention of menstrual syndrome and postmenopausal hot flushes. The normal western diet contains little ALA (less than 50% of the RDA). The only adequate sources are rapeseed oil (canola), walnuts and so-called "omega-3" eggs (similar to wild-type or Cretan eggs). The amounts of EPA and DHA in the diet vary greatly from person to person. The only good sources are fish and seafood, together with "omega-3" eggs.
本综述详细阐述了女性对ω-3脂肪酸的特定需求,包括α-亚麻酸(ALA)以及极长链脂肪酸二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)。ω-3脂肪酸(通过饮食或胶囊摄入)可确保女性的脂肪组织为发育中的胎儿和母乳喂养的新生儿储备这些脂肪酸。这能确保婴儿大脑和认知的最佳发育。饮食中大量的EPA和DHA会使孕期稍有延长,并改善孕期质量。与其他哺乳动物不同,母乳中同时含有ALA和DHA。糖尿病等病症会改变母乳的脂肪酸组成,而某些饮食,如素食者、纯素食者甚至是长寿饮食,如果不包含海鲜,也会产生同样的效果。ALA、DHA和EPA对预防各年龄段女性的缺血性心血管疾病都很重要。ω-3脂肪酸有助于预防某些癌症的发生,尤其是乳腺癌和结肠癌,也可能预防子宫癌和皮肤癌,并可能降低产后抑郁症、躁郁症、痴呆症(阿尔茨海默病等)、高血压、毒血症、糖尿病以及在一定程度上与年龄相关的黄斑变性的风险。ω-3脂肪酸在预防月经综合征和绝经后潮热方面可能发挥积极作用。西方的常规饮食中ALA含量很少(低于推荐膳食摄入量的50%)。唯一充足的来源是菜籽油(加拿大菜油)、核桃和所谓的“ω-3”鸡蛋(类似于野生型或克里特岛鸡蛋)。饮食中EPA和DHA的含量因人而异。唯一的优质来源是鱼类和海鲜,以及“ω-3”鸡蛋。