Bilhan H, Bilgin T, Cakir A F, Yuksel B, Von Fraunhofer J A
Faculty of Dentistry, Department of Removable Prosthodontics Istanbul University, 34390 - Capa, Istanbul, Turkey.
J Biomater Appl. 2007 Nov;22(3):197-221. doi: 10.1177/0885328207072557. Epub 2007 Jan 25.
The corrosion of dental alloys has biological, functional, and aesthetic consequences. Various studies have shown that protein solutions can inhibit the corrosion of alloys. This study is planned to determine the relationship of organic constituents of saliva and the corrosion of dental alloys. The organic constituents are IgA, mucine, urea, and lysozyme which are encountered in the highest amounts in saliva and the dental materials are titanium (Ti), Co-Cr-Mo and Ni-Cr-Mo alloys, and dental amalgam, the most often used metallic components in dentistry. In particular, the interactions between the commonest salivary proteins, IgA, mucine, urea and lysozyme, and Ti, Co-Cr-Mo, Ni-Cr-Mo and dental amalgam were investigated. Each alloy was evaluated by cyclic polarization in each medium. The general anodic and cathodic behavior during forward and reverse cycles, the corrosion and passivation current densities (muA/cm2 ), and the corrosion and the pitting potentials (mV) were determined. The results have shown that Ni-Cr-Mo and dental amalgam alloys are highly susceptible to corrosion in all the investigated media. The Co-Cr-Mo alloy has shown high passive current densities in the solution of mucine and lysozyme in artificial saliva. Titanium instead, has shown a high resistance to corrosion and a stable passive behavior in all media, especially in a solution of mucine and IgA in synthetic saliva. Mucine and IgA, as well as urea and lysozyme, appeared to enhance the formation of a passive film layer on the Ti metal surface, thus inhibiting the corrosion. Based on the study findings, and especially considering the problem of nickel allergy and toxicity of mercury released from dental amalgam, the use of Co-Cr-Mo alloys and Ti to Ni-Cr-Mo alloys is recommended and alternatives to dental amalgam should be sought for patients with impaired salivary flow.
牙科合金的腐蚀具有生物学、功能和美学方面的影响。各种研究表明，蛋白质溶液可以抑制合金的腐蚀。本研究旨在确定唾液有机成分与牙科合金腐蚀之间的关系。有机成分包括唾液中含量最高的免疫球蛋白A（IgA）、粘蛋白、尿素和溶菌酶，牙科材料包括钛（Ti）、钴铬钼合金和镍铬钼合金，以及牙科汞合金，这是牙科中最常用的金属成分。特别地，研究了最常见的唾液蛋白IgA、粘蛋白、尿素和溶菌酶与Ti、钴铬钼、镍铬钼和牙科汞合金之间的相互作用。每种合金在每种介质中通过循环极化进行评估。测定了正向和反向循环过程中的一般阳极和阴极行为、腐蚀和钝化电流密度（微安/平方厘米）以及腐蚀和点蚀电位（毫伏）。结果表明，镍铬钼合金和牙科汞合金在所有研究介质中都极易腐蚀。钴铬钼合金在人工唾液中的粘蛋白和溶菌酶溶液中表现出高钝化电流密度。相反，钛在所有介质中都表现出高耐腐蚀性和稳定的钝化行为，尤其是在合成唾液中的粘蛋白和IgA溶液中。粘蛋白和IgA以及尿素和溶菌酶似乎增强了Ti金属表面钝化膜层的形成，从而抑制了腐蚀。基于研究结果，特别是考虑到镍过敏问题和牙科汞合金释放汞的毒性，建议使用钴铬钼合金和钛替代镍铬钼合金，对于唾液分泌受损的患者应寻求牙科汞合金的替代品。
