Bockarie Moses J, Tavul Livingstone, Ibam Irvin, Kastens Will, Hazlett Fred, Tisch Daniel J, Alpers Michael P, Kazura James W
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Am J Trop Med Hyg. 2007 Jan;76(1):62-6.
The efficacy of diethylcarbamazine alone was compared with diethylcarbamazine plus albendazole in residents of an island in Papua New Guinea endemic for Wuchereria bancrofti. There was no statistically significant difference between the two drug regimens in decreasing the microfilaria positive rate at 12 and 24 months after a single-dose treatment with either regimen, e.g., 50.0% clearance of microfilaria at 24 months for diethylcarbamazine alone versus 65.7% clearance of microfilaria for diethylcarbamazine plus albendazole (P > 0.05). In contrast, diethylcarbamazine plus albendazole resulted in a significant decrease in Og4C3 antigen prevalence (17%; P = 0.003) at 24 months whereas diethylcarbamazine did not (10%; P = 0.564). These data showed no statistically significant difference in the efficacy of the two drug regimens in lowering the microfilaria reservoir, but they support the use of diethylcarbamazine combined with albendazole in mass treatment programs on the basis of greater activity against adult worms.
在巴布亚新几内亚一个班氏吴策线虫流行的岛屿上，对仅使用乙胺嗪与乙胺嗪加阿苯达唑治疗居民的效果进行了比较。两种药物治疗方案在单剂量治疗后12个月和24个月降低微丝蚴阳性率方面无统计学显著差异，例如，仅使用乙胺嗪时24个月微丝蚴清除率为50.0%，而乙胺嗪加阿苯达唑时微丝蚴清除率为65.7%（P>0.05）。相比之下，乙胺嗪加阿苯达唑在24个月时导致Og4C3抗原流行率显著下降（17%；P = 0.003），而乙胺嗪则未导致下降（10%；P = 0.564）。这些数据表明，两种药物治疗方案在降低微丝蚴库方面的疗效无统计学显著差异，但基于对成虫更强的活性，支持在群体治疗项目中使用乙胺嗪联合阿苯达唑。
