干细胞分裂中母源与子代中心体的不对称遗传。
Asymmetric inheritance of mother versus daughter centrosome in stem cell division.
作者信息
Yamashita Yukiko M, Mahowald Anthony P, Perlin Julie R, Fuller Margaret T
机构信息
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.
出版信息
Science. 2007 Jan 26;315(5811):518-21. doi: 10.1126/science.1134910.
Abstract
Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both populations. The asymmetric outcome of stem cell divisions can be specified by an oriented spindle and local self-renewal signals from the stem cell niche. Here we show that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line. The mother centrosome remains anchored near the niche while the daughter centrosome migrates to the opposite side of the cell before spindle formation.
摘要
成体干细胞通常进行不对称分裂，产生一个自我更新的干细胞和一个分化细胞，从而维持这两种细胞群体。干细胞分裂的不对称结果可由定向纺锤体和来自干细胞微环境的局部自我更新信号来确定。在这里，我们表明，发育程序设定的不对称行为以及母中心体和子中心体的遗传是果蝇雄性生殖系中干细胞分裂的定型纺锤体定向和不对称结果的基础。母中心体保持锚定在微环境附近，而子中心体在纺锤体形成之前迁移到细胞的另一侧。
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