Protective effect of liposome-entrapped superoxide dismutase and catalase on bleomycin-induced lung injury in rats. II. Phospholipids of the lung surfactant.

The influence of liposome-entrapped catalase and/or superoxide dismutase on phospholipids of the lung surfactant in bleomycin-treated rats was investigated. Changes in phospholipid composition of lung surfactant were much pronounced in animals supplemented with antioxidant enzymes-loaded liposomes. It is suggested that liposomes are good carriers for drugs in bleomycin-induced lung injury treatment.