一种来自曲霉属真菌的新型氢化氮杂蒽酮Sch 725680

A new hydrogenated azaphilone Sch 725680 from Aspergillus sp.

作者信息

Yang Shu-Wei, Chan Tze-Ming, Terracciano Joseph, Patel Reena, Patel Mahesh, Gullo Vincent, Chu Min

机构信息

Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

出版信息

J Antibiot (Tokyo). 2006 Nov;59(11):720-3. doi: 10.1038/ja.2006.96.

DOI:10.1038/ja.2006.96

PMID:17256471

Abstract

A new hydrogenated azaphilone Sch725680 (1) was isolated and identified from the culture of an Aspergillus sp. The structure elucidation of 1 was achieved based on extensive NMR spectroscopic analyses. Compound 1 showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 64 microg/ml, respectively.

摘要

从一株曲霉属真菌的培养物中分离并鉴定出一种新的氢化氮杂蒽酮Sch725680（1）。基于广泛的核磁共振光谱分析确定了1的结构。化合物1对酿酒酵母（PM503）和白色念珠菌（C43）具有抑制活性，其最低抑菌浓度分别为8和64微克/毫升。