来自铜色毛壳菌Chaetomium cupreum CC3003的抗真菌氮杂环庚三烯酮
Antifungal azaphilones from the fungus Chaetomium cupreum CC3003.
作者信息
Kanokmedhakul Somdej, Kanokmedhakul Kwanjai, Nasomjai Pitak, Louangsysouphanh Sysavad, Soytong Kasem, Isobe Minoru, Kongsaeree Palangpon, Prabpai Samran, Suksamrarn Apichart
机构信息
Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
出版信息
J Nat Prod. 2006 Jun;69(6):891-5. doi: 10.1021/np060051v.
Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50 values of 10.5, 16.7, 24.3, and 0.6 microg/mL, respectively.
从真菌铜色毛壳菌CC3003中分离出三种新的氮杂蒽酮，命名为rotiorinols A - C（1 - 3）、两种新的立体异构体（-）-rotiorin（4）和表异嗜色菌素II（5），以及一种已知化合物红曲菌素（6）。结构通过光谱证据确定。1的绝对构型通过改进的莫舍尔方法、其乙酸酯衍生物的X射线分析以及化学转化来确定。化合物1、3、4和6对白色念珠菌表现出抗真菌活性，IC50值分别为10.5、16.7、24.3和0.6微克/毫升。
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