Gandia J A, Giménez-Amaya J M
Department of Morphology, Faculty of Medicine, University Autonomous of Madrid, Spain.
J Hirnforsch. 1991;32(1):79-88.
Anterograde and retrograde experiments were made in the rat using either a mixture of horseradish peroxidase free and wheat germ-agglutinated (HRP-WGA) or HRP-WGA unmixed, in an attempt to investigate how the striatopallidal pathway is organized from rostral territories of the rat's striatum. The main findings emerging from this study are: a) a remarkable projection is directed from the rostral pole of the caudate-putamen complex to rostral sectors of the globus pallidus (GP) and entopeduncular nucleus (EP) and its is organized in a topographical fashion; b) this projection presents a remarkable heterogeneity in the distribution of terminal labeling into the GP and EP; c) a heterogeneous distribution of retrogradely labeled cells was seen in the rostral striatum after retrograde tracer injections in the GP that might explain, at least partially, the heterogeneity observed in the anterograde experiments.
利用游离辣根过氧化物酶和麦胚凝集素混合物（HRP-WGA）或未混合的HRP-WGA对大鼠进行了顺行和逆行实验，旨在研究大鼠纹状体的嘴侧区域如何构建纹状体苍白球通路。本研究得出的主要结果如下：a）从尾壳核复合体的嘴极向苍白球（GP）和内囊核（EP）的嘴侧部分发出显著投射，且呈拓扑学方式构建；b）该投射在GP和EP内终末标记的分布上呈现出显著的异质性；c）在GP中注射逆行示踪剂后，在嘴侧纹状体中观察到逆行标记细胞的异质性分布，这可能至少部分解释了在顺行实验中观察到的异质性。
