Ruilope L M
Hypertension Unit, 12 de Octubre Hospital, Madrid, Spain.
J Cardiovasc Pharmacol. 1991;18 Suppl 5:S10-3.
Calcium-entry blockers exert several characteristic effects on the kidney that potentiate their antihypertensive effect. Long-term therapy with nitrendipine, a dihydropyridine derivative, lowers blood pressure while maintaining renal hemodynamics within limits similar to pretreatment values in essential hypertension with normal renal function. This is accompanied by a persistent natriuretic effect that probably facilitates its antihypertensive action and is not followed by changes of the renin-angiotensin-aldosterone system. Preliminary data also seem to indicate that nitrendipine could be safely used in patients with arterial hypertension and chronic renal failure.
钙通道阻滞剂对肾脏有多种独特作用，可增强其降压效果。使用二氢吡啶衍生物尼群地平进行长期治疗，可降低血压，同时在肾功能正常的原发性高血压患者中，使肾脏血流动力学维持在与治疗前值相似的范围内。这伴随着持续的利钠作用，这可能有助于其降压作用，且不会引起肾素-血管紧张素-醛固酮系统的变化。初步数据似乎还表明，尼群地平可安全用于动脉高血压和慢性肾衰竭患者。
