Fujiwara T, Yoshioka J, Ohmoto T
Department of Neurological Surgery, Kagawa Medical School.
Neurol Med Chir (Tokyo). 1991 Oct;31(10):654-7. doi: 10.2176/nmc.31.654.
A 44-year-old female with malignant astrocytoma received subtotal removal and high dose (200 mg/m2) intra-arterial 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chloroethyl)-3-nitrosourea hydrochloride (ACNU) with autologous bone marrow transplantation. Tumor remission with minimal bone marrow suppression was achieved. However, she developed severe encephalopathy and computed tomographic scans revealed a low-density area at the ACNU delivery site. She received glycerol solution to treat the brain edema and recovered completely from the encephalopathy. Intra-arterial ACNU exceeding 200 mg/m2 possibly causes neurotoxicity.
一名44岁的恶性星形细胞瘤女性患者接受了次全切除，并接受了高剂量（200mg/m²）的动脉内1-（4-氨基-2-甲基-5-嘧啶基）甲基-3-（2-氯乙基）-3-亚硝基脲盐酸盐（ACNU）治疗及自体骨髓移植。实现了肿瘤缓解且骨髓抑制轻微。然而，她出现了严重的脑病，计算机断层扫描显示ACNU给药部位有低密度区。她接受了甘油溶液治疗脑水肿，并完全从脑病中康复。动脉内ACNU超过200mg/m²可能会引起神经毒性。
