Hirano Y, Mineura K, Mizoi K, Tomura N
Department of Neurosurgery, Akita University Hospital, Akita-pref. 010-8543, Japan.
Int J Oncol. 1998 Sep;13(3):537-42. doi: 10.3892/ijo.13.3.537.
Thirty-three adult patients with anaplastic astrocytoma or glioblastoma multiforme, verified between 1990 and 1997, received postoperative intra-arterial ACNU chemotherapy and irradiation. Since our previous strategies to malignant gliomas had included intra-venous ACNU, the purpose of the present study is to evaluate the advantage of intra-arterial ACNU over its intra-venous counterpart as the historical control (37 patients). The median survival was 74.7 weeks for the former and 81.7 weeks for the latter. Although both groups were equivalent in survival, toxicity was less frequent in the intra-arterial group. Histopathological diagnosis, patient age and the Karnofsky's performance status related well with the survival.
1990年至1997年间确诊的33例间变性星形细胞瘤或多形性胶质母细胞瘤成年患者接受了术后动脉内阿糖胞苷（ACNU）化疗和放疗。由于我们之前对恶性胶质瘤的治疗策略包括静脉注射阿糖胞苷，本研究的目的是评估动脉内阿糖胞苷相对于静脉注射阿糖胞苷（作为历史对照，37例患者）的优势。前者的中位生存期为74.7周，后者为81.7周。虽然两组生存期相当，但动脉内给药组的毒性反应较少见。组织病理学诊断、患者年龄和卡诺夫斯基（Karnofsky）功能状态与生存期密切相关。
